Craig Blackstone Selected Research

Hereditary Spastic Paraplegia

11/2022	Inhibiting mitochondrial fission rescues degeneration in hereditary spastic paraplegia neurons.
1/2022	Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia.
9/2020	Loss of the Mitochondrial Fission GTPase Drp1 Contributes to Neurodegeneration in a Drosophila Model of Hereditary Spastic Paraplegia.
1/2020	Hereditary spastic paraplegia SPG8 mutations impair CAV1-dependent, integrin-mediated cell adhesion.
1/2019	Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III.
1/2017	De novo REEP2 missense mutation in pure hereditary spastic paraplegia.
12/2016	Reep1 null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation.
5/2015	Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia.
12/2014	Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.
11/2014	Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A.

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Craig Blackstone Research Topics

Disease

22	Hereditary Spastic Paraplegia 11/2022 - 12/2003
10	autosomal dominant Spastic paraplegia 3 01/2022 - 12/2003
5	Paraplegia (Spastic Paraplegia) 01/2022 - 04/2012
4	autosomal recessive Spastic paraplegia 20 08/2012 - 09/2005
3	Dystonia (Limb Dystonia) 06/2009 - 05/2003
2	Nervous System Diseases (Neurological Disorders) 01/2022 - 10/2010
2	Starvation 01/2022 - 05/2013
2	Cicatrix (Scar) 01/2020 - 03/2016
2	Adducted Thumbs) Syndrome Shuffling Gait Aphasia MASA (Mental Retardation 01/2017 - 12/2016
2	Parkinsonian Disorders (Parkinsonism) 09/2015 - 08/2007
2	Infantile Parkinsonism-Dystonia 01/2011 - 06/2009
1	Nerve Degeneration 11/2022
1	Fatty Liver 01/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2020
1	Guillain-Barre Syndrome 12/2019
1	Microcephaly 12/2019
1	Dengue (Dengue Fever) 11/2019
1	autosomal dominant Spastic paraplegia 10 01/2017
1	Lipodystrophy 12/2016
1	Spastic paraplegia 17 12/2016
1	Disease Susceptibility (Diathesis) 01/2016
1	Cognitive Dysfunction 09/2015
1	Alzheimer Disease (Alzheimer's Disease) 01/2015
1	Inclusion Body Myositis 12/2014
1	autosomal recessive 1 Spinocerebellar ataxia 09/2014
1	Cerebellar Ataxia (Dysmetria) 09/2014
1	Huntington Disease (Huntington's Disease) 07/2014
1	Neurologic Gait Disorders (Gait, Hemiplegic) 09/2013
1	Fatty Acid Hydroxylase-Associated Neurodegeneration 04/2012
1	Spastic Ataxia 10/2011
1	Osteomyelitis 01/2011
1	Bipolar Disorder (Manic Depressive Psychosis) 06/2009
1	autosomal recessive Segawa syndrome 06/2009
1	Neuroblastoma 01/2009
1	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 05/2008
1	Spastic Paraplegia Type 7 05/2008
1	Primary Immunodeficiency Diseases 08/2007
1	Agammaglobulinemia (Hypogammaglobulinemia) 08/2007
1	Bruton type agammaglobulinemia 08/2007
1	Parkinson Disease (Parkinson's Disease) 09/2003
1	Deafness (Deaf Mutism) 05/2003
1	Optic Atrophy 05/2003

Drug/Important Bio-Agent (IBA)

24	Proteins (Proteins, Gene)FDA Link 11/2022 - 05/2003
9	GTP Phosphohydrolases (GTPases)IBA 01/2022 - 12/2003
6	SpastinIBA 01/2022 - 04/2010
4	Dynamins (Dynamin)IBA 01/2011 - 12/2003
2	Triglycerides (Triacylglycerol)IBA 01/2022 - 05/2013
2	Adenosine Triphosphatases (ATPase)IBA 01/2022 - 04/2010
2	Carrier Proteins (Binding Protein)IBA 01/2022 - 12/2003
2	Wiskott-Aldrich Syndrome ProteinIBA 01/2020 - 03/2016
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2019 - 04/2012
2	DNA (Deoxyribonucleic Acid)IBA 05/2015 - 09/2014
1	Small Interfering RNA (siRNA)IBA 11/2022
1	Biomarkers (Surrogate Marker)IBA 11/2022
1	Alanine Transaminase (SGPT)IBA 01/2022
1	Liver X ReceptorsIBA 01/2022
1	Conditioned Culture MediaIBA 12/2020
1	GW 3965IBA 12/2020
1	CholesterolIBA 12/2020
1	IntegrinsIBA 01/2020
1	Viral AntibodiesIBA 11/2019
1	ATPases Associated with Diverse Cellular ActivitiesIBA 01/2019
1	sperm releasing substanceIBA 01/2018
1	Nonsense Codon (Nonsense Mutation)IBA 09/2015
1	Amyloid (Amyloid Fibrils)IBA 01/2015
1	Chemokine CX3CL1IBA 01/2015
1	Protein AggregatesIBA 12/2014
1	Staphylococcal Protein A (Protein A)IBA 09/2014
1	RNA Helicases (RNA Helicase)IBA 09/2014
1	IronIBA 04/2012
1	IsoenzymesIBA 10/2011
1	m-AAA proteasesIBA 10/2011
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2011
1	AmphetaminesIBA 06/2009
1	Dopamine (Intropin)FDA LinkGeneric 06/2009
1	Cocaine (Cocaine HCl)IBA 06/2009
1	CaspasesIBA 01/2009
1	Caspase 8 (Caspase-8)IBA 01/2009
1	Protein Isoforms (Isoforms)IBA 05/2008
1	Serine Proteases (Serine Protease)IBA 05/2008
1	PresenilinsIBA 05/2008
1	Metalloproteases (Metalloproteinases)IBA 05/2008
1	NucleotidesIBA 04/2008
1	Intravenous Immunoglobulins (IVIG)FDA Link 08/2007
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 08/2007
1	GuanosineIBA 06/2007
1	ErbB Receptors (EGF Receptor)IBA 05/2007
1	Proteasome Endopeptidase Complex (Proteasome)IBA 09/2003
1	UbiquitinIBA 09/2003
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 05/2003

Therapy/Procedure

3	Therapeutics 07/2014 - 08/2007
1	Surgical Amputation (Amputations) 01/2011